Metástasis

METASTASIS

A metastasis is the dissemination of the cancer of an organ or corporal part to another region or organ nonconnected in direct form with first, the metastasis are growth of remote cancerous cells of their primary residence

Cell s which they are in the malignant tumors can invade and damage near weave s and organ s. Cancerous cell s can separate of the malignant tumor and also travel by the blood or the system linf attic to form new tumors in other parts of the body.  The Biology of the metastasis is a selective process and not a random event, in this tranformacion cellular (I diria travel cellular) is possible to emphasize the following steps:

1. ANGIOGENESIS (proseso by which it increases the amount of glasses and the primary tumor in growth is nourished)
2. LOOSENING AND LOCOMOTION (after invading the interstitial weave the cells you vitiate penetrate in the lymphatic routes or vasculares, translation:  they are given off cel.de the primary tumor and they travel by the extracellular matrix)
3. INTRAVASACION (they enter the sanguineous torrent)

4. EXTRUSION (Exit of the circulation: the tumorlike cells are catched in capìlares where they adhere to the endoteliales cells, extruding the tumorlike cells by mechanisms similar to the people in charge of the local invasion of the tumor. bony s alen of the sanguineous torrent)

5. INVASION (invades distant weave s or organs: the extruded tumorlike cells begin to grow in answer to the factors of growth and signals autocrinas of the guest. In this growth they need a vascular contribution, reason why many tumors secretan factors of vascular growth to develop new blood vessels. This process denominates angiogénesis)

 

Neoplasias you vitiate are scattered by different routes:

• Sowing in corporal cavities
• Hemática dissemination
• Lymphatic dissemination

 

• Sowing in Corporal Cavities: This sowing happens when neoplasia invades a natural cavity of the body. Usually she is attacked the peritoneal cavity, but it can be the pleural, pericárdica, subaracnoide and also articulate.

•   Hematica dissemination: The tumorlike cells follow the blood flow that drains the site of neoplasia. The liver and the lungs are the affected ones most frequently since all drenage of the region porthole flows towards the liver and all the blood of the veins diggings flows towards the lungs. The dissemination in arteries is less frequent than in the veins because the penetration is less fast. He is typical of sarcomas. But also it they can use the carcinomas

•  Lymphatic dissemination: There is a great number of interconnections between the vascular system and lymphatic reason why the cancer forms can be scattered by one or another route. The pattern of affection of the lymphatic ganglia depends to a great extent on the site of neoplasia primary and the lymphatic route. The tumorlike cells are introduced in the lymphatic conduits and produce embolia in the regional ganglia when obstructing the filtration of the lymph. It is the most typical propagation of the carcinomas.

 

 

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